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KMID : 0378019740170070918
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New Medical Journal
1974 Volume.17 No. 7 p.918 ~ p.927
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Experimental Studies of the Effect of Tetracycline on Mineralization and Growth in Rats
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Abstract
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For the purpose of studying the effect of tetracycline on mineralization and growth, the rats were given a daily dose of 40mg. /kg. /day and 80mg. /kg. /day of tetracycline during the 8th-15th day of gestation.
The effect of tetracycline on young rats delivered from adult rats receiving tetracycline had been assessed mainly through studies of body weight, length of tibia, size of mandible and contents of calcium. The latter was determined by atomic absorption spectrophotometry.
The results were drawn as follows.
1. Tetracycline had the inhibitory effects on growth and mineralization in rats.
2. The more dosage of tetracycline had the severer inhibitory effects on growth and mineralization in rats.
3. The inhibitory effect on body weight was observed in group 1 (40mg. /kg. /day) during the 1st week after delivery, in group 2 (80mg. /kg. /day) during the 3rd week after delivery. The highest value of depression rate on body weight was 28.7% in group 2 (80mg. /kg. /day) at the 1st day after delivery.
4. The inhibitory effect on growth rate of tibia was observed in group 1 (40mg. /kg. /day) during the 2nd week after delivery, in group 2 (80mg. /kg. /day) during the 3rd week. after 4elivery. The highest value of depression rate on tibia growth was 36. 2% in group 2 (80mg. /kg. /&a.y) at the 1st day after delivery.
5. The inhibitory effect on growth rate of mandible was observed in group 1 (40mg. /kg. /day) during the 1st week after´ delivery, in group 2 (80mg. /kg. /day) during the 3rd week after deiivery.
6. The calcium contents on mandible, tibia, anterior teeth and posterior teeth were incraasel in group 1 (40mg. /kg. /day) during the 1st week after delivery, in group 2 (80mg. /kg. /day) during the 4th week after delivery.
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